Nature Health Study Analyzes Reddit Reports of Side Effects from GLP-1 Weight-Loss Drugs
An analysis in Nature Health examined Reddit posts from 70,000 users on GLP-1 medications like Ozempic and Mounjaro, revealing menstrual irregularities and temperature complaints not listed on labels. Nausea topped reported symptoms at 37 percent. Researchers noted these as signals for further investigation.
GB News# Study Reveals Unlabeled Side Effects of Weight-Loss Injections An analysis published in the journal Nature Health identified menstrual irregularities and temperature-related complaints as potential effects of weight-loss injections such as Ozempic and Mounjaro, effects not included on official labels.
American scientists examined posts from approximately 70,000 Reddit users spanning more than six years to identify symptoms reported by those taking GLP-1 medications. The study assessed social media posts spanning from May 2019 to June 2025.
GLP-1 medications were originally developed for diabetes management. Nearly four per cent of the Reddit users in the sample reported menstrual irregularities.
Common Symptoms Reported by Users Nausea was the most reported symptom at nearly 37 per cent among Reddit users taking GLP-1 medications.
Fatigue was reported at just under 17 per cent among Reddit users taking GLP-1 medications. 3 per cent among Reddit users taking GLP-1 medications. 3 per cent among Reddit users taking GLP-1 medications.
6 per cent among Reddit users taking GLP-1 medications. These findings come from the analysis of user posts on Reddit.
Expert Commentary on Findings Neil Sehgal stated: "But nearly four per cent of the Reddit users in our sample reported menstrual irregularities, which would be even higher in a female-only sample.
" Professor Lyle Ungar, from the University of Pennsylvania, stated that clinical trials typically identify the most dangerous adverse effects but may miss symptoms that concern patients most. " The study highlights potential gaps in labeling for these medications.
Broader Context and Regulatory Actions More than 1.
6 million adults across the United Kingdom are estimated to be using weight loss injections, including Wegovy and Mounjaro. The MHRA issued warnings earlier this year regarding semaglutide medications Wegovy and Ozempic, alerting patients to heightened risks of non-arteritic anterior ischaemic optic neuropathy and acute pancreatitis.
The MHRA stated that the overall likelihood of developing pancreatitis while taking semaglutide medications remains very rare.
Story Timeline
3 events- 2026-04-15
Analysis published in Nature Health on menstrual irregularities and temperature complaints from GLP-1 drugs.
1 sourceNature Health journal - 2026 (earlier this year)
MHRA issued warnings on semaglutide medications for risks of optic neuropathy and pancreatitis.
1 sourceMHRA - May 2019 to June 2025
Researchers assessed Reddit posts from 70,000 users on GLP-1 medications.
1 sourceresearchers
Potential Impact
- 01
Increased investigation into menstrual effects could lead to label updates for GLP-1 drugs.
- 02
Higher reported female-specific side effects could affect prescribing in women's health.
- 03
Patient awareness of unlabeled symptoms may influence usage rates of Ozempic and Mounjaro.
- 04
Regulatory bodies like MHRA may expand monitoring based on social media data signals.
Transparency Panel
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