Phage-Delivered CRISPR-Cas12 System Developed to Target Shiga Toxin Gene in E. coli
@ScienceMagazine reported on a new precision antimicrobial that combines CRISPR-Cas12 with phage delivery to address Shiga toxin-producing E. coli infections in animals.
thehindu.comA team encapsulated an engineered CRISPR-Cas12 therapeutic inside a phage therapy delivery system to create a precision antimicrobial for Shiga toxin-producing E. coli. The system is designed to cleave the Stx gene that produces the toxin.
@ScienceMagazine reported that the therapy combats infection in animals. The approach pairs the gene-cutting activity of CRISPR-Cas12 with the bacteria-targeting capability of phages. Researchers developed the construct specifically for strains that carry the Stx gene.
The work focuses on animal infections caused by these toxin-producing bacteria.
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