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Researchers Report Kilogram-Scale Synthesis of Cholesterol Drug Enlicitide
A Science study describes a new production method for enlicitide, a peptide in Phase 3 trials for lowering LDL cholesterol. The route uses engineered enzymes and crystallization steps to reduce reaction count and raise yield.
May 24, 2:09 PM·1m read1 source
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Researchers published a kilogram-scale synthesis method for enlicitide in Science. The peptide is currently in a Phase 3 clinical trial for lowering low-density lipoprotein cholesterol. The reported route relies on engineered enzymes and crystallization of key intermediates.
It reduces the number of reaction steps and improves overall yield compared with prior approaches. A SciencePerspective accompanying the paper outlines the technical details of the enzymatic and crystallization sequence.
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