Study Finds No Link Between Acetaminophen Use in Pregnancy and Autism in Children

A study published this week in JAMA Pediatrics examined the potential link between acetaminophen use during pregnancy and autism in children. 5 million children born in Denmark between 1997 and 2022. 0% of those not exposed.

The findings indicate no effect of acetaminophen, known by the brand name Tylenol, on autism development. A related study from Sweden, which focused on siblings, also found no causal link. Genetic associations and environmental triggers are likely involved in autism, but neither acetaminophen nor vaccines have been shown to cause it.

The new study follows statements from the administration urging pregnant women to avoid acetaminophen without substantive evidence.

During a press event at the White House in September, a statement advised against taking the drug unless necessary for severe fever. The FDA then began a process to update the safety label on acetaminophen to suggest a link to autism during pregnancy.

Medical organizations, such as the American College of Obstetricians and Gynecologists, responded by noting that acetaminophen is one of the few safe options for treating pain and fever in pregnancy.

Untreated fever and pain can be harmful, and alternatives like ibuprofen are generally not recommended due to risks of complications.

The administration's claims led to confusion among pregnant women.

A prior study reported a 16% drop in acetaminophen use in emergency departments following the announcement. The company that makes Tylenol issued a statement disagreeing with suggestions of a link to autism, citing independent science showing no causation, and expressed concern over health risks to expecting mothers.