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Structural Study Reveals How Omicron Affects Antibody Access to Conserved S2′ Site in Spike Protein

A Nature study details how SARS-CoV-2 Omicron variants evade antibody 76E1 by steric hindrance in an early fusion intermediate conformation of the spike protein. Researchers found that minimizing antibody size reversed evasion mechanisms and boosted neutralizing activity against…