Chlorpromazine-Promethazine Combination Tested for Safety in Inducing Hypothermia

Researchers used chlorpromazine and promethazine to induce hypothermia that lowered metabolism and body temperature in large animals, protecting them from stroke, @ScienceMagazine reported. The same drug combination was tested in a phase one clinical trial that established its safety. The approach relies on the two approved medications to trigger a controlled drop in body temperature.

This state reduces metabolic demand during periods when blood flow to the brain is interrupted. @ScienceMagazine reported that the phase one trial focused solely on safety and did not assess efficacy against stroke in humans.