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Review Finds Vitamin D and Calcium Supplements Do Not Prevent Fractures or Falls

A systematic review of 69 randomized trials involving more than 150,000 participants found that supplementation with vitamin D or calcium, or both, does not reduce fractures or falls. The analysis examined multiple dosing regimens and participant groups.

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1 source·May 20, 10:37 PM(8 days ago)·1m read
Review Finds Vitamin D and Calcium Supplements Do Not Prevent Fractures or Fallsindianexpress.com
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A new systematic review of 69 randomized trials with more than 150,000 participants found that vitamin D or calcium supplementation, or both, does not prevent fractures or falls. The review evaluated different doses and combinations across varied populations. Results showed no meaningful reduction in either outcome.

Researchers analyzed data from trials that tested vitamin D alone, calcium alone, and the two supplements together. No regimen demonstrated a statistically significant benefit for fracture or fall prevention. The findings update earlier assessments that had reached similar conclusions on supplementation effectiveness.

Key Facts

69 randomized trials
included in systematic review
More than 150,000 participants
across all trials analyzed
No reduction in fractures or falls
observed with vitamin D or calcium supplementation

Potential Impact

  1. 01

    Clinicians may reconsider routine supplementation recommendations for fracture and fall prevention.

Transparency Panel

Sources cross-referenced1
Confidence score75%
Synthesized bySubstrate AI
Word count91 words
PublishedMay 20, 2026, 10:37 PM
Bias signals removed1 across 1 outlet
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