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Researchers Create Fictional Illness; Chatbots Diagnose It as Real in Nature Study

Two preprints about a fictional illness called bixonimania were taken down from the Preprints.org server on 10 April. Popular chatbots had been diagnosing users with the made-up condition based on common eye symptoms over the past 18 months. The illness was created by a researcher along with fake studies funded by fictional entities.

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1 source·Apr 28, 1:55 PM(8 days ago)·1m read
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Org server on 10 April, according to a Nature report. A researcher created the fictional illness named bixonimania and produced fake studies funded by the Professor Sideshow Bob Foundation, the University of the Fellowship of the Ring, and the Galactic Triad. Large language models warned people that the fictional illness bixonimania was real, as detailed in the Nature coverage.

Millions of people spend too much time staring at screens and being bombarded with blue light, which can lead to symptoms like sore, itchy eyes and pinkish eyelids. In the past 18 months, typing symptoms of sore, itchy eyes and pinkish eyelids into popular chatbots resulted in responses diagnosing bixonimania, Nature reported.

Key Facts

Preprints removal
On 10 April, two preprints on bixonimania were taken down from the Preprints.org server.
Fictional illness creation
A researcher created bixonimania and fake studies funded by the Professor Sideshow Bob Foundation, University of the Fellowship of the Ring, and the Galactic Tr
Chatbot diagnoses
In the past 18 months, popular chatbots diagnosed users with bixonimania based on symptoms like sore, itchy eyes and pinkish eyelids.
Screen exposure data
Millions of people spend too much time staring at screens and being bombarded with blue light.

Story Timeline

4 events
  1. 2026-04-10

    Two preprints on bixonimania were taken down from the Preprints.org server.

    1 source@Nature
  2. 2024-10-28 to 2026-04-28 (past 18 months)

    Typing symptoms of sore, itchy eyes and pinkish eyelids into popular chatbots resulted in responses diagnosing bixonimania.

    1 sourceunattributed
  3. Recent (undated)

    Large language models warned people that the fictional illness bixonimania was real.

    1 sourceunattributed
  4. Recent (undated)

    A researcher created the fictional illness bixonimania and fake studies funded by the Professor Sideshow Bob Foundation, University of the Fellowship of the Ring, and the Galactic Triad.

    1 sourceunattributed

Potential Impact

  1. 01

    Heightened public awareness of AI limitations in medical advice.

  2. 02

    Increased scrutiny on AI chatbots for spreading health misinformation.

  3. 03

    Possible research into improving LLM fact-checking for health queries.

  4. 04

    Potential updates to preprint servers' policies on fictional or hoax submissions.

Transparency Panel

Sources cross-referenced1
Framing risk28/100 (low)
Confidence score65%
Synthesized bySubstrate AI
Word count111 words
PublishedApr 28, 2026, 1:55 PM
Bias signals removed3 across 2 outlets
Signal Breakdown
Loaded 2Speculative 1

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