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South Africa to Begin Lenacapavir HIV Prevention Injections in Mpumalanga on June 5

Health Minister Dr Aaron Motsoaledi announced the rollout of the twice-yearly HIV prevention drug, with stocks arriving in two weeks and initial distribution to 360 facilities in high-burden districts. The Global Fund for HIV, TB and Malaria will finance the programme for South Africa and other poorer countries.

AllAfrica
1 source·May 13, 3:36 PM(16 days ago)·1m read
South Africa to Begin Lenacapavir HIV Prevention Injections in Mpumalanga on June 5citizen.co.za
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South Africa will launch Lenacapavir on June 5 in Mpumalanga, Health Minister Dr Aaron Motsoaledi said after delivering the department's budget vote on Wednesday. In the next two weeks, Lenacapavir stocks will be delivered to depots and health facilities. The rollout will start with 360 health facilities in the high burden districts of South Africa.

Lenacapavir is administered via injection twice a year. It offers patients six months of continuous protection per dose. The Global Fund for HIV, TB and Malaria will fund the roll-out of lenacapavir for poorer countries including South Africa.

Prioritised categories for Lenacapavir are adolescent girls and young women up to age 24 years, pregnant and breastfeeding mothers, female sex workers, men-having-sex-with-men, transgender people and injecting drug users, Motsoaledi explained. 9 years by 2025 from a low of 54 years in 2010.

The country has reduced maternal mortality to 89 deaths per 100,000 live births by 2020 from a high of 240 deaths per 100,000 live births in 2010.

3 in 2010. 7 per 100,000 population from a high of 988 per 100,000 population in 2015. AllAfrica reported that these gains followed the world's largest HIV counselling, testing and treatment campaign.

Motsoaledi stated the country is now in a position where it can eliminate HIV/AIDS as a public health threat if South Africans "work hard and work hard together". "As a country we know what is at stake because we had achieved results which are there for everybody to see," he said. Motsoaledi warned that cancer is becoming a major challenge.

Cervical cancer is the 2nd biggest killer of women after breast cancer. Sixty-five percent of all women with diagnosed cervical cancer in South Africa are also HIV+. The WHO formula for cervical cancer elimination is 90-70-90.

South Africa has modified the formula because it bears the world's highest HIV/AIDS burden.

Key Facts

Lenacapavir launch scheduled for June 5 in Mpumalanga
Stocks arrive in two weeks for initial rollout at 360 facilities in high-burden districts; prioritised groups include adolescent girls and young women up to 24,
Global Fund to finance Lenacapavir rollout
Funding provided for poorer countries including South Africa regardless of U.S. Pepfar support; drug given as twice-yearly injection offering six months protect
South Africa reports major health gains since 2010
Life expectancy up from 54 to 66.9 years by 2025; maternal mortality down from 240 to 89 per 100,000; under-5 mortality from 74.3 to 27.7 per 1,000; TB incidenc
Modified 90-70-90 strategy adopted for cervical cancer
Sixty-five percent of women diagnosed with cervical cancer are HIV-positive; South Africa extended screening age range by 10 years on each end due to highest gl

Story Timeline

7 events
  1. 2026-05-13

    Health Minister Dr Aaron Motsoaledi delivers department's budget vote and announces Lenacapavir launch details

    2 sourcesAllAfrica · SAnews.gov.za
  2. 2026-05-27

    Lenacapavir stocks scheduled for delivery to depots and health facilities

    1 sourceAllAfrica
  3. 2026-06-05

    Official launch of Lenacapavir to be held in Mpumalanga

    2 sourcesAllAfrica · SAnews.gov.za
  4. 2010

    Life expectancy at 54 years, maternal mortality at 240 per 100,000 live births, under-5 mortality at 74.3 per 1,000 live births

    1 sourceAllAfrica
  5. 2015

    TB incidence at peak of 988 per 100,000 population

    1 sourceAllAfrica
  6. 2020

    Maternal mortality reduced to 89 deaths per 100,000 live births

    1 sourceAllAfrica
  7. 2025

    Life expectancy reaches 66.9 years and under-5 mortality falls to 27.7 per 1,000 live births

    1 sourceAllAfrica

Potential Impact

  1. 01

    Initial access for thousands in high-burden districts through 360 facilities within weeks

  2. 02

    Reduced daily pill burden for prioritised high-risk populations

  3. 03

    Potential decline in cervical cancer mortality among HIV-positive women through expanded HPV vaccination and DNA screening

  4. 04

    Accelerated progress toward HIV elimination as public health threat

Transparency Panel

Sources cross-referenced1
Confidence score75%
Synthesized bySubstrate AI
Word count305 words
PublishedMay 13, 2026, 3:36 PM
Bias signals removed1 across 1 outlet
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