Topic
clinical trials
60 stories related to this topic, newest first.
New Scientistscience19 hrs ago
Four of 33 Children Survive Years After Experimental T-Cell Therapy in Early Safety Trial
New Scientist reported that four children with aggressive brain tumors survived years after receiving tumour-associated antigen T-cell therapy in a phase-I trial. Three show no evidence of disease. The approach is now advancing in two follow-on studies.
news.sky.comscience22 hrs ago
UK Regulator Clears First Human Trials of Oxford Ebola Vaccine
The Medicines and Healthcare Products Regulatory Agency cleared phase-one testing of the University of Oxford vaccine. The trial will begin within weeks and involve 50 healthy adults in the UK.
abcnews.go.comworld1 day ago
Ebola Treatment Trial Enrolls First Patients in Congo Six Weeks After WHO Declares Emergency
The Partners trial tests remdesivir and MBP134 against the Bundibugyo strain. As of 9 July the outbreak recorded 1,792 confirmed cases and 625 deaths.
marketscreener.comscience4 days ago
AstraZeneca Shares Fall 9% After Wainua Heart Drug Trial Misses Primary Endpoint
London-listed shares of the British drugmaker dropped as much as 9 percent Thursday after late-stage results showed Wainua failed to reduce deaths and heart events in patients with transthyretin-mediated amyloid cardiomyopathy. The outcome also pushed shares of partner Ionis Phar…
marketscreener.comscience4 days ago
AstraZeneca shares fall after Wainua trial misses death reduction goal
AstraZeneca shares declined after its drug Wainua did not lower death rates in a heart condition study. The company reported the trial results and investors reacted to the outcome.
abcnews.go.comworld8 days ago
Researchers Begin Trial of Two Ebola Treatments in Eastern Congo
A study evaluating remdesivir and an experimental antibody treatment for the Bundibugyo virus opened this week at a treatment center in Bunia. The trial is supported by the World Health Organization and several international partners.
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winnipegfreepress.comworld9 days ago
Researchers Begin Trial of Two Experimental Treatments for Bundibugyo Ebola Outbreak in Eastern Congo
A clinical study evaluating remdesivir and MBP134 began in early July at an Ebola treatment center in Bunia. The trial will track survival for 28 days after treatment starts and may expand to high-risk groups in a second phase.
world10 days ago
DRC Begins Trial of Two Experimental Ebola Treatments
Health authorities in the Democratic Republic of Congo have started a clinical trial of two experimental Ebola drugs while the outbreak continues to expand in the northeast. The study tests monoclonal antibody MBP134 and antiviral remdesivir against the Bundibugyo strain.
abcnews.go.comworld10 days agoUpdated
DRC Begins Trial of Experimental Ebola Treatments as Outbreak Spreads
Health authorities in the Democratic Republic of Congo have started a clinical trial of two experimental Ebola therapies while the outbreak centered in Ituri province continues to expand. The study is testing a monoclonal antibody and an antiviral drug against the Bundibugyo stra…
abcnews.go.comworld11 days ago
Ebola Treatment Trial Begins in Democratic Republic of Congo
A clinical trial of two experimental therapeutics for the Bundibugyo strain of Ebola has started in the Democratic Republic of Congo. The World Health Organization announced the enrollment of the first patient on Thursday.
science11 days ago
Roche Lung-Cancer Drug Candidate Outperforms Standard Treatments in Late-Stage Trial
A Roche experimental lung-cancer therapy showed better results than current standard treatments in a late-stage clinical trial. The company reported the outcome through a Wall Street Journal account.
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science12 days ago
Amylyx and Biogen to Release Biotech Trial Results This Quarter
Stat reported upcoming data from Amylyx's Phase 3 study of avexitide and detailed results from Biogen's mid-stage Alzheimer's trial. The events form part of the publication's third-quarter biotech scorecard.
Statscience13 days ago
Abivax Releases Additional Maintenance Trial Data on Obefazimod
Abivax released additional Phase 3 maintenance trial data for obefazimod late Monday. The update showed cancer rates aligned with background expectations after earlier concerns. U.S.-listed shares gained about 25% overnight.
science14 days ago
Talawar Therapeutics to list publicly through reverse merger with JATT II Acquisition Corp and $225 million financing
@statnews reported that Talawar Therapeutics plans to go public through a reverse merger with JATT II Acquisition Corp. The transaction includes a $225 million PIPE financing. The company said the funds will support its lead program through mid-stage clinical testing.
theconversation.comscience14 days ago
Drug Combination Cooled Body Temperature After Stroke in Animals and Humans but Showed No Reduction in Brain Damage
Promethazine and chlorpromazine cooled core body temperature in mice and rhesus monkeys after induced strokes and reduced resulting brain damage. A 32-person human trial showed a 0.3 °C drop but no measurable benefit on damage, leading to a planned follow-up with faster dosing.
Semaforworld17 days ago
U.S. to supply experimental Ebola drug to Congo for trial
The U.S. will provide an experimental drug for use in a clinical trial in the region. Officials initially limited the drug to American use but later expanded access for the trial.
jns.orgscience20 days ago
HHS Sends Monoclonal Antibody Doses for Ebola Clinical Trial in Africa
The Department of Health and Human Services has sent doses of the monoclonal antibody MBP-134 to support a clinical trial. The trial protocol is under review by authorities in the Democratic Republic of the Congo and Uganda.
New York Postfinance21 days ago
LSD Therapy Shows Significant Benefit in Major Depression Phase 3 Trial
Definium Therapeutics reported that a single dose of its LSD-based pill DT120 produced a 13.3-point drop on a standard depression scale after six weeks, compared with 5.2 points for placebo. The effect remained largely intact at 12 weeks.
New York Postscience21 days ago
Definium Shares Rise 55% After LSD-Based Drug Meets Main Goal in Depression Trial
Definium Therapeutics reported that a single dose of its experimental drug DT120 reduced major depression symptoms in a late-stage trial. Shares jumped 55% to a more than four-year high.
gizmodo.comscience21 days ago
Chlorpromazine-Promethazine Combination Tested for Safety in Inducing Hypothermia
Researchers used the two drugs to lower metabolism and body temperature in large animals. The combination proved safe in a phase one clinical trial. @ScienceMagazine reported the results.
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newatlas.comscience21 days agoUpdated
Definium LSD therapy reduced depression scores in Phase 3 trial
Definium Therapeutics reported that its LSD-based drug DT120 produced larger reductions in depression scores than placebo in a late-stage study. The company said the results move the therapy closer to potential regulatory review.
science22 days ago
Drugmakers test compounds to limit muscle loss during weight reduction
Several pharmaceutical companies are developing medicines that aim to preserve lean mass while patients lose fat. Early human data and repurposed compounds are entering mid-stage trials.
newscientist.comscience24 days ago
Pancreatic Cancer Drug Extends Survival in International Study
An international study presented May 31 reported longer survival for pancreatic cancer patients taking daraxonrasib. The FDA granted early access to the drug one month earlier for selected patients.
thehindu.comscience26 days ago
Trial finds modest reductions in kidney injury and death with cefazolin or benzylpenicillin versus flucloxacillin for staph bloodstream infections
A world-first study across 150 hospitals in 14 countries showed two alternative antibiotics produced lower kidney damage and mortality rates than the standard treatment.
finance26 days ago
Paradromics Implants Brain-Chip Device in Patient for First Time
A University of Michigan team implanted Paradromics' Connexus brain-chip device in a woman with a motor neuron disease in early June. The patient is now recovering at home and will begin testing the device in the coming weeks to restore communication ability.
benzinga.comscience27 days ago
Verge Labs Releases AI Model After Phase 1b ALS Drug Trial Fails With One-Third Dropout
The company formerly known as Verge Genomics published a postmortem on its failed Phase 1b ALS trial and introduced a new AI model for patient stratification in neurology studies.
fortune.comscience27 days ago
Inventiva Raises €130m in Debt Financing Led by Claret Capital Partners
Claret Capital Partners committed €43m to Inventiva’s €130m financing closed on 16 June 2026. BlackRock-managed funds also participated in the round.
marketwatch.comscience28 days ago
Elicio Shares Fall After Pancreatic Cancer Vaccine Misses Mid-Stage Primary Endpoint
Elicio shares declined after its pancreatic cancer vaccine failed to meet primary and key efficacy endpoints in a mid-stage clinical trial, according to @Reuters reported.
themarketherald.com.aubusiness28 days ago
European Clinical Trial Registry Shows Low Results Reporting Rates
An analysis of a key European database found results reported on time for fewer than half of registered studies, with complete results available for 42 percent.
The Guardianscience29 days ago
Poolbeg Pharma to begin small trial of oral drug for preventing cytokine release syndrome in cancer patients at six NHS hospitals
The London startup will begin an intermediate trial of POLB 001 in 30 patients receiving Johnson & Johnson’s teclistamab. The study is led by the University of Manchester and the Christie NHS Foundation Trust.
The Sydney Morning Heraldworld29 days ago
Monash University Begins Trial of Psilocybin Therapy for Long-Term Concussion Effects
Researchers will test whether a single dose of psilocybin combined with therapy can ease persistent symptoms in people with mild traumatic brain injury. The study has received federal funding and is recruiting participants who have had symptoms for at least six months.
uctoday.comscience30 days ago
Trials Begin on Drugs Targeting Current Ebola Outbreak
Several experimental treatments are entering clinical trials after showing early activity against the virus driving the widening outbreak. Health authorities are expanding testing capacity as case numbers rise.
medpagetoday.comscience30 days ago
Mitapivat Cuts Transfusions but Misses Main Pain-Crisis Goal in Sickle-Cell Trial
Agios Pharmaceuticals presented new Phase 3 data showing mitapivat reduced transfusion burden and raised hemoglobin in sickle cell disease patients. The results were unveiled at the European Hematology Association Congress in Stockholm.
manilatimes.netscience32 days ago
Adial Pharmaceuticals buys Azora Therapeutics and raises $64 million via private placement of warrants
Adial Pharmaceuticals acquired Azora Therapeutics on June 11, 2026, alongside a private placement of up to $64 million. The deal funds advancement of Azora's colon-targeted therapy for ulcerative colitis.
forbes.comfinance32 days ago
Targeted Drug Extended Median Survival by About Six Months Versus Chemotherapy in Advanced Triple-Negative Breast Cancer Trial
More than 640 patients received either the antibody-drug conjugate or chemotherapy as first-line treatment. The targeted therapy extended median progression-free survival to nearly 11 months versus just under 6 months with chemotherapy.
Euronewsscience33 days ago
U.S. biotech firm begins first human test of gene therapy for cellular ageing
A Boston-based biotechnology company has started the first clinical trial of a gene therapy intended to reverse cellular ageing. The treatment, called ER-100, targets optic nerve damage and has moved into Phase 1 safety testing.
insidermonkey.compolitics33 days ago
CervoMed Raises $10.5 Million in Private Placement
CervoMed Inc. announced a private placement expected to generate $10.5 million in gross proceeds. The company said the funds will extend its cash runway into the second quarter of 2027 and support efforts to secure a partner for Phase 3 development of neflamapimod in dementia wit…
theconstructionindex.co.ukscience33 days ago
Cullinan Reports Early Phase 1 Data on CLN-978 and Velinotamig in Small Cohorts of RA and SLE Patients
The Cambridge-based company released Phase 1 results showing remissions in rheumatoid arthritis and lupus patients. Plans for Phase 2a expansion and additional trials were also outlined.
manilatimes.netscience34 days ago
Small Subgroup Analysis Finds Stronger Heart-Failure Risk Reduction With Dapagliflozin in Cardiomyopathy Variant Carriers
A Nature Medicine analysis of the DECLARE-TIMI 58 trial found dapagliflozin produced an eightfold greater reduction in heart failure hospitalization among carriers of cardiomyopathy-linked genetic variants than among non-carriers.
Wiredscience34 days ago
Life Biosciences Begins Human Trial of Cellular Rejuvenation Drug for Optic Nerve Conditions
A Boston-based company has started dosing adults in the first human study of ER-100, a therapy designed to restore function in optic-nerve cells damaged by glaucoma or NAION. The trial will track safety and side effects in roughly 18 participants over the next year.
The Independentscience35 days ago
Oxford University and Moderna to begin cancer vaccine trials this summer
A vaccine developed by Oxford University and Moderna will enter clinical testing this summer in patients with Lynch syndrome. The trial will assess whether the mRNA shot can train the immune system to destroy pre-cancerous cells before tumors form.
medpagetoday.comscience35 days ago
Gilead and Merck Say HIV Pill Combination Hits Primary Goal in Phase 3 Trials
The companies reported that their long-acting combination pill reached its main efficacy target in late-stage testing.
qz.comscience35 days ago
Survodutide Achieves 13% Weight Loss and Up to 63% Liver-Fat Reduction in Phase 3 Trial, Trailing Existing GLP-1 Drugs
Patients lost 13 percent of body weight on the highest dose after 76 weeks. Liver-fat reduction exceeded placebo by a wide margin.
world35 days ago
Zealand Pharma's Survodutide Meets Key Targets in Phase 3 Trial but Sees 19% Discontinuation Rate Due to GI Side Effects
The Danish drugmaker's stock fell sharply after late-stage data showed 19% of patients discontinued survodutide due to gastrointestinal side effects, compared with 2.9% on placebo.
foxbusiness.comworld35 days ago
Zealand Pharma Shares Fall 20% After Weight-Loss Drug Trial Shows High Discontinuation Rate
The Danish company's stock dropped sharply Monday after trial participants discontinued use of its experimental weight-loss treatment at high rates.
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The Guardianscience36 days ago
New Pancreatic Cancer Drug Doubles Survival Time in Trial
A daily pill extended median survival from 6.5 to 13.5 months for patients with advanced pancreatic cancer in a 500-person study. Separate early trials showed a smart drug shrank tumors in six common cancers, and observational data linked GLP-1 weight-loss drugs to lower cancer r…
science36 days ago
Survodutide Achieves 63% Liver Fat Reduction and 13% Weight Loss in Phase 3 Obesity Trial
Boehringer Ingelheim’s weekly injectable reduced liver fat more than placebo but produced 13 percent weight loss after 76 weeks, below rates for Wegovy and Zepbound.
foxnews.comscience36 days ago
Experimental Drug Added to Standard Therapy Yields 19% Functional Cure Rate for Chronic HBV in Two Trials, Only in Already-Controlled Patients
A six-month course of an experimental drug combined with existing antivirals produced functional cures in 19 percent of participants whose chronic hepatitis B infections were already well controlled.
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cnbc.comscience37 days ago
Retatrutide Shows Strong Blood-Sugar and Weight-Loss Benefits in Diabetes Trial With Limited Cardiac Events
New safety figures from Eli Lilly’s TRANSCEND-T2D-1 study were released Saturday at the American Diabetes Association meeting and published in the Lancet.
thehindubusinessline.comscience37 days ago
Pfizer Reports Phase 2b Results for Monthly GLP-1 Drug Berobenatide
Pfizer's experimental GLP-1 receptor agonist berobenatide showed strong blood-sugar control and weight-loss effects in a Phase 2b trial. The company said the drug was generally well tolerated and supported further testing of once-monthly dosing.
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Nbc Newsscience37 days ago
Pfizer and Amgen Report Midstage Data on Experimental Monthly GLP-1 Drugs for Weight Loss
Pfizer and Amgen are advancing monthly GLP-1 drugs that could reduce injections from 52 to 12 per year. Early trial data show weight loss and blood-sugar control with side effects similar to weekly versions.
manilatimes.netpolitics37 days ago
Cullinan Therapeutics Presents Phase 1 Data on CLN-978 at EULAR 2026 Congress
Cullinan Therapeutics reported initial clinical results from two Phase 1 trials of CLN-978, a CD19xCD3 T cell engager, in patients with systemic lupus erythematosus and rheumatoid arthritis. The data were presented June 6 at the European Alliance of Associations for Rheumatology…
prnewswire.comscience38 days ago
Rivus Pharmaceuticals Presents Preclinical Non-Human Primate Data on Oral GLP-1 Candidate RV-8451 at ADA Meeting
Rivus Pharmaceuticals announced preclinical results for its oral GLP-1 receptor agonist RV-8451 at the American Diabetes Association's 86th Scientific Sessions on June 5, 2026.
Statscience38 days ago
Patient Reports Benefit from Revolution Medicines’ Daraxonrasib as Oncologists Applaud Data but Biotech Stocks Fall
Leanna Stokes, diagnosed with metastatic pancreatic cancer in 2023, discussed her experience in a Revolution Medicines clinical trial on a June 4, 2026 podcast. Oncologists gave a standing ovation to data on the company’s drug daraxonrasib presented at last week’s American Societ…
thequint.comscience38 days ago
Large NCI-Funded Phase 3 Trial Tests Probiotic CBM588 With Immunotherapy in Advanced Kidney Cancer
A multicenter study funded by the National Cancer Institute will test whether CBM588 improves outcomes when taken with immunotherapy in nearly 700 people with advanced renal cell carcinoma.
The Independentai39 days ago
AI Vaccine Targets Virus Families in Early Human Trial
A DNA vaccine created with machine learning produced immune responses to multiple coronaviruses in a phase I study of 49 volunteers. Researchers plan a phase II trial with more than 200 participants. The approach aims to address shared viral features rather than individual strain…
Statscience39 days ago
Pancreatic Cancer Patient in Clinical Trial Plans to Seek Expanded Access to Daraxonrasib if Needed
Amy Johnston, 35, of Gilbertsville, Pa., plans to request daraxonrasib if her current trial fails. The drug nearly doubled survival time in earlier testing and is now available through an expanded access program.
thehindubusinessline.comfinance39 days ago
Rezolute to Present Four Studies on Hyperinsulinism at Endocrine Society Meeting
Rezolute, Inc. will deliver one oral presentation and three poster presentations at the Endocrine Society annual meeting in Chicago from June 13-16, 2026. The presentations cover clinical trial results and outcomes data related to congenital and tumor-associated hyperinsulinism.
Substrate placeholder — needs reviewworld40 days ago
Small Phase-2 Trial Finds 85% of Bladder Cancer Patients Cancer-Free at One Year With Added Immunotherapy
A phase-two study found that adding durvalumab to chemotherapy and radiotherapy kept cancer from returning in 46 of 54 patients. The approach may allow some patients to avoid bladder removal surgery.
prnewswire.comworld41 days ago
UK to Trial Enhanced Prostate Screening for Black Men Aged 45-74 With £18m Investment
The government will invest £18 million to invite black men aged 45-74 into the Transform trial. The move follows a National Screening Committee recommendation against routine PSA testing for most men.
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